Howard Hughes Medical Institute, The Rockefeller University, New York, New York, USA.
Nat Neurosci. 2010 May;13(5):615-21. doi: 10.1038/nn.2526. Epub 2010 Apr 4.
Many neurons release classical transmitters together with neuropeptide co-transmitters whose functions are incompletely understood. Here we define the relationship between two transmitters in the olfactory system of C. elegans, showing that a neuropeptide-to-neuropeptide feedback loop alters sensory dynamics in primary olfactory neurons. The AWC olfactory neuron is glutamatergic and also expresses the peptide NLP-1. Worms with nlp-1 mutations show increased AWC-dependent behaviors, suggesting that NLP-1 limits the normal response. The receptor for NLP-1 is the G protein-coupled receptor NPR-11, which acts in postsynaptic AIA interneurons. Feedback from AIA interneurons modulates odor-evoked calcium dynamics in AWC olfactory neurons and requires INS-1, a neuropeptide released from AIA. The neuropeptide feedback loop dampens behavioral responses to odors on short and long timescales. Our results point to neuronal dynamics as a site of behavioral regulation and reveal the ability of neuropeptide feedback to remodel sensory networks on multiple timescales.
许多神经元会一起释放经典递质和神经肽共递质，但其功能尚未完全了解。在这里，我们定义了秀丽隐杆线虫嗅觉系统中两种递质之间的关系，表明神经肽到神经肽的反馈环改变了初级嗅觉神经元的感觉动态。AWC 嗅觉神经元是谷氨酸能的，也表达肽 NLP-1。具有 nlp-1 突变的蠕虫表现出增加的 AWC 依赖性行为，表明 NLP-1 限制了正常反应。NLP-1 的受体是 G 蛋白偶联受体 NPR-11，它在突触后 AIA 中间神经元中起作用。AIA 中间神经元的反馈调节 AWC 嗅觉神经元中气味诱发的钙动力学，需要 INS-1，这是一种从 AIA 释放的神经肽。神经肽反馈在短时间和长时间尺度上抑制对气味的行为反应。我们的结果指出神经元动态是行为调节的一个位点，并揭示了神经肽反馈在多个时间尺度上重塑感觉网络的能力。
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