随着年龄增长的认知衰退：不仅仅是前后摇摆。
cognitive decline with age: more than just wiggling forward and backward.
作者信息
Sengupta Titas, Murphy Coleen T
机构信息
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
出版信息
Genes Dev. 2025 Aug 1;39(15-16):933-935. doi: 10.1101/gad.353115.125.
Abstract
has been at the forefront of research on mechanisms of age-related decline for the past 30 years. Despite its popularity in longevity research, is underappreciated for its potential to study complex behaviors and the progressive decline in these functions with age. Using assays of learning and memory, we have identified genetic pathways that regulate these behaviors and identified new mechanisms to boost these functions with age in both worms and mice. Because is so highly conserved, some of these recently described mechanisms may be good targets to prevent human cognitive decline with age.
摘要
在过去30年里一直处于与年龄相关衰退机制研究的前沿。尽管它在长寿研究中很受欢迎，但它在研究复杂行为以及这些功能随年龄的渐进衰退方面的潜力却未得到充分重视。通过学习和记忆检测，我们已经确定了调节这些行为的基因途径，并确定了在蠕虫和小鼠中随着年龄增长增强这些功能的新机制。由于它的保守性非常高，一些最近描述的机制可能是预防人类年龄相关性认知衰退的良好靶点。
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