神经酰胺二半乳糖苷作为日本软海绵（Halichondria japonica）中主要糖鞘脂的存在情况。
Occurrence of ceramide digalactoside as the main glycosphingolipid in the marine sponge Halichondria japonica.
作者信息
Hayashi A, Nishimura Y, Matsubara T
机构信息
Department of Chemistry, Faculty of Science and Technology, Kinki University, Higashiosaka, Japan.
出版信息
Biochim Biophys Acta. 1991 May 8;1083(2):179-86. doi: 10.1016/0005-2760(91)90040-o.
The main glycosphingolipid of the sponge Halichondria japonica was isolated and its structure was determined to be ceramide digalactoside, Gal alpha 1----4Gal beta 1----1Cer, using FAB/MS, IR, 1H-NMR and chemical methods such as permethylation analysis and degradation techniques. The ceramide moiety was composed mainly of 4-hydroxy-iso-octadecasphinganine and 2-hydroxy-docosanoic acid. Interestingly, the branched long-chain bases were comprised of 70% total long-chain bases and 17.5% 4-hydroxy-anteiso-nonadecasphinganine. Ceramide monohexoside, consisting of galactosyl ceramide (81%) and glucosyl ceramide (19%), was also isolated as a minor component. The composition of the ceramide moiety was nearly the same as that of ceramide digalactoside.
对日本软海绵（Halichondria japonica）的主要糖鞘脂进行了分离，并采用快原子轰击质谱（FAB/MS）、红外光谱（IR）、核磁共振氢谱（1H-NMR）以及诸如全甲基化分析和降解技术等化学方法确定其结构为神经酰胺二半乳糖苷，即Galα1----4Galβ1----1Cer。神经酰胺部分主要由4-羟基异十八碳鞘氨醇和2-羟基二十二烷酸组成。有趣的是，支链长链碱占总长链碱的70%，4-羟基异壬基十九碳鞘氨醇占17.5%。神经酰胺单己糖苷作为次要成分也被分离出来，它由半乳糖基神经酰胺（81%）和葡萄糖基神经酰胺（19%）组成。神经酰胺部分的组成与神经酰胺二半乳糖苷的组成几乎相同。
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