Boonyapisit Warangkna, Tresukosol Damras
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2010 Jan;93 Suppl 1:S48-53.
Imidapril is an angiotensin converting enzyme (ACE) inhibitor without a sulfhydril group which has been shown from previous study to have low incidence of ACE inhibitor induced cough.
To compare the incidence of cough between two ACE inhibitors, imidapril and enalapril.
A comparative cross over study was performed in 119 patients with hypertension or left ventricular dysfunction. Patients were assigned to one of the two treatment groups, either a group receiving imidapril or enalapril for 4 weeks (Period I) and then these same groups were crossed over to receive either enalapril or imidapril for 4 weeks (Period II). The occurrence of cough during treatment was monitored by interviewing the patients.
The incidence of cough was 44 % while on imidapril treatment and 66% while on enalapril treatment (p = 0.0014). The antihypertensive effects of two drugs were not different.
The incidence of cough was significantly less under imidapril than under enalapril treatment, while there was no difference in the antihypertensive effects between the two ACE inhibitors.
咪达普利是一种不含巯基的血管紧张素转换酶（ACE）抑制剂，先前的研究表明其由ACE抑制剂引起咳嗽的发生率较低。
比较两种ACE抑制剂（咪达普利和依那普利）引起咳嗽的发生率。
对119例高血压或左心室功能不全患者进行了一项比较性交叉研究。患者被分配到两个治疗组之一，一组接受咪达普利或依那普利治疗4周（第一阶段），然后这两组交叉接受依那普利或咪达普利治疗4周（第二阶段）。通过询问患者来监测治疗期间咳嗽的发生情况。
接受咪达普利治疗时咳嗽的发生率为44%，接受依那普利治疗时为66%（p = 0.0014）。两种药物的降压效果无差异。
咪达普利治疗下咳嗽的发生率明显低于依那普利治疗，而两种ACE抑制剂的降压效果无差异。
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