Andronova V L, Galegov G A, Ias'ko M V, Kukhanova M K, Skoblov Iu S
Vopr Virusol. 2010 Jan-Feb;55(1):31-4.
The ability of acycloguanosine H-phosphate to inhibit the reproduction of herpes simplex virus type 1 (HSV-1) variants, including its acycloguanosine (acyclovir)-resistant ones, was studied. Acycloguanosine H-phosphate-resistant HSV-1 variants were obtained. It was found that these variants were cross-resistant to thymidine kinase-dependent HSV reproduction inhibitors, but preserved sensitivity to Apa-A and phosphonoacetic acid.
研究了阿昔洛韦氢磷酸盐抑制1型单纯疱疹病毒（HSV-1）变体（包括其对阿昔洛韦耐药的变体）复制的能力。获得了对阿昔洛韦氢磷酸盐耐药的HSV-1变体。发现这些变体对依赖胸苷激酶的HSV复制抑制剂具有交叉耐药性，但对阿帕-A和膦甲酸仍保持敏感性。
