van den Berg E, van Doormaal J J, Oosterhuis J W, de Jong B, Buist J, Vos A M, Dam A, Vermeij A
Department of Pathology, University of Groningen, The Netherlands.
Cancer Genet Cytogenet. 1991 May;53(1):15-21. doi: 10.1016/0165-4608(91)90110-g.
We describe cytogenetics of a case of nodular hyperplasia of the thyroid with papillary microcarcinoma following radiotherapy for Hodgkin's disease. The chromosomal pattern found was very heterogeneous with a clonal abnormality of chromosome 10, among others. Together with some recent data from the literature, this finding may point to an important role of chromosome 10 abnormalities in the pathogenesis of benign and malignant thyroid neoplasms.
我们描述了1例霍奇金病放疗后发生甲状腺结节性增生伴微小乳头状癌的细胞遗传学情况。所发现的染色体模式非常异质性，其中包括10号染色体的克隆性异常。结合文献中的一些最新数据，这一发现可能表明10号染色体异常在甲状腺良恶性肿瘤发病机制中起重要作用。
