Albiglutide: a new GLP-1 analog for the treatment of type 2 diabetes.

IMPORTANCE OF THE FIELD

Despite the wide array of treatments available, a significant number of patients with type 2 diabetes continue to remain uncontrolled. The discovery of the incretin hormones and their role in glucose homeostasis has brought about a new class of medications called the glucagon-like peptide-1 (GLP-1) analogs. This new class of medications provides the benefits of weight loss as well as a lack of hypoglycemia. However, the currently available agents require once or twice daily injections.

AREAS COVERED IN THIS REVIEW

Relevant literature will be discussed on albiglutide, a new GLP-1 analog in Phase III clinical trials. Several clinical trials examining the use of albiglutide as combination therapy are currently ongoing.

WHAT THE READER WILL GAIN

To date, results of clinical trials suggest that albiglutide may provide a more attractive dosing profile compared with the currently available GLP-1 analogs.

TAKE HOME MESSAGE

The results of ongoing trials will help define the role of albiglutide in treating patients with type 2 diabetes.