Zhou Zhi-Ming, Yang Song, Yue Xuan-Ye, Zhu Wu-Sheng, Ma Min-Min, Xu Ge-Lin, Liu Xin-Feng
Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Zhonghua Yi Xue Za Zhi. 2010 Feb 23;90(7):451-3.
To investigate the relationship between cerebral microbleeds (CMB), cardiovascular risk factors, and plasma fibrinogen in patients with acute ischemic stroke.
Sixty-eight patients with acute ischemic stroke from June 2008 to March 2009 were enroued prospectively. All patients received cranial magnetic resonance imaging at the first week, and T2(*)-weighted gradient echo MRI sequence was performed to detect CMB. Plasma fibrinogen, uric acid levels and other biochemical parameters were measured on the next day of admission. All data were selected from Nanjing Stroke Registry Program.
Among a total 68 patients, 29 (43%) patients had 109 lesions of cerebral microbleeds on gradient-echo MRI. Age, hypertension, fibrinogen and uric acid were significantly associated with the presence of CMB (P = 0.004, 0.024, 0.020, 0.027 respectively). Through a logistic regression analysis, age, hypertension and plasma fibrinogen were significantly associated with the presence of cerebral microbleeds [(P = 0.02, OR = 1.10, 95%CI 1.02 to 1.19; P = 0.003, OR = 9.35, 95%CI 2.17 to 40.23; P = 0.019, OR = 1.01, 95%CI 1.00 to 1.02].
There is a high prevalence of CMB in patients with acute ischemic stroke. And it has a strong relationship with high plasma fibrinogen.
探讨急性缺血性脑卒中患者脑微出血（CMB）、心血管危险因素与血浆纤维蛋白原之间的关系。
前瞻性纳入2008年6月至2009年3月期间的68例急性缺血性脑卒中患者。所有患者在第一周接受头颅磁共振成像检查，并采用T2（*）加权梯度回波MRI序列检测CMB。入院次日测定血浆纤维蛋白原、尿酸水平及其他生化指标。所有数据均选自南京卒中登记项目。
68例患者中，29例（43%）在梯度回波MRI上有109个脑微出血病灶。年龄、高血压、纤维蛋白原和尿酸与CMB的存在显著相关（分别为P = 0.004、0.024、0.020、0.027）。通过逻辑回归分析，年龄、高血压和血浆纤维蛋白原与脑微出血的存在显著相关[（P = 0.02，OR = 1.10，95%CI 1.02至1.19；P = 0.003，OR = 9.35，95%CI 2.17至40.23；P = 0.019，OR = 1.01，95%CI 1.00至1.02]。
急性缺血性脑卒中患者CMB的患病率较高，且与高血浆纤维蛋白原密切相关。
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