Chen Ying-Fa, Chang Yung-Yee, Liu Jia-Shou, Lui Chun-Chung, Kao Yi-Fen, Lan Min-Yu
Department of Neurology, Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung University College of Medicine, 123, Ta-Pei Road, Niao-Sung, Kaohsiung County 833, Taiwan.
Clin Neurol Neurosurg. 2008 Dec;110(10):988-91. doi: 10.1016/j.clineuro.2008.06.003. Epub 2008 Jul 26.
To investigate association between cerebral microbleeds (CMB) and prior intracerebral hemorrhage (ICH) on MRI and topographic correlation of the two types of lesions.
Two hundred and sixty consecutive patients (67.0+/-11.1 years) with ischemic stroke were included. CMB and prior ICH were assessed on T2-gradient-echo MRI. The presence and number of CMB as predictors for prior ICH were examined. Topographic correlations between CMB and ICH lesions in patients with prior ICH in the infratentorial, basal ganglionic/thalamic and cortico-subcortical regions were tested.
CMB were observed in 113 (43.5%) patients and a total of 50 prior primary ICH lesions were observed in 39 (15.0%) patients. Among the ICH lesions, 39 (78%) were asymptomatic. Presence of CMB (odds ratio 2.53, p=0.015) and number of CMB (odds ratio 1.11, p<0.001) were independent determinants for prior ICH. Topographic correlation between CMB and ICH was significant in the basal ganglionic/thalamic region (p=0.017), but not in the infratentorial (p=0.548) or cortico-subcortical regions (p=0.389).
CMB were associated with prior ICH on MRI of patients with ischemic stroke. CMB in the basal ganglion or thalamus was associated with prior ICH in the same region.
研究脑微出血（CMB）与既往脑出血（ICH）在磁共振成像（MRI）上的相关性以及这两种类型病变的地形相关性。
纳入260例连续的缺血性卒中患者（67.0±11.1岁）。通过T2梯度回波MRI评估CMB和既往ICH。检查CMB的存在情况和数量作为既往ICH预测指标。测试幕下、基底节/丘脑和皮质-皮质下区域既往有ICH患者中CMB与ICH病变的地形相关性。
113例（43.5%）患者观察到CMB，39例（15.0%）患者共观察到50处既往原发性ICH病变。在ICH病变中，39处（78%）无症状。CMB的存在（比值比2.53，p = 0.015）和CMB的数量（比值比1.11，p < 0.001）是既往ICH的独立决定因素。CMB与ICH在基底节/丘脑区域的地形相关性显著（p = 0.017），但在幕下区域（p = 0.548）或皮质-皮质下区域（p = 0.38）不显著。
缺血性卒中患者MRI上CMB与既往ICH相关。基底节或丘脑中的CMB与同一区域的既往ICH相关。
