Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
Diab Vasc Dis Res. 2009 Apr;6(2):94-9. doi: 10.1177/1479164109336046.
We describe the lipoprotein and apolipoprotein profiles and their relationship to cardiovascular risk factors in Australian Aboriginal children. This cross-sectional study within a longitudinal birth cohort study involved Australian Aboriginal children born between 1987 and 1990 and re-examined between 1998 and 2001. Height, weight, blood pressure, waist circumference, body fat percentage, cholesterol, triglycerides, HDL-c, LDL-c, apolipoprotein B and A1 were measured. Mean age was 11.4 years (52% male). Mean cholesterol, triglyceride, HDL-c and LDL-c did not differ from reference data. Measures of obesity, blood pressure and prevalence of the metabolic syndrome did not differ in those children with lipoproteins in the upper quartile of the cohort (lower quartile for HDL-c). Boys with an Apo-B/A1 ratio in the upper quartile of the cohort had higher BMI z-score, waist z-score, % body fat, diastolic blood pressure and frequency of the metabolic syndrome (p<0.05). In girls, waist circumference, % body fat and the prevalence of the metabolic syndrome was higher in those with an Apo-B/A1 ratio in the upper quartile (p<0.05).The Apo-B/A1 ratio may be useful to identify cardiovascular risk in Australian Aboriginal children and is suited to clinical practice as the assays are standardised, accurate, automated and a fasting sample is not required.
我们描述了澳大利亚原住民儿童的脂蛋白和载脂蛋白谱及其与心血管危险因素的关系。这是一项在纵向出生队列研究中进行的横断面研究，涉及 1987 年至 1990 年间出生的澳大利亚原住民儿童，并于 1998 年至 2001 年期间重新检查。测量了身高、体重、血压、腰围、体脂百分比、胆固醇、甘油三酯、HDL-c、LDL-c、载脂蛋白 B 和 A1。平均年龄为 11.4 岁（52%为男性）。胆固醇、甘油三酯、HDL-c 和 LDL-c 的平均值与参考数据没有差异。在脂蛋白处于队列前四分之一的儿童中，肥胖、血压和代谢综合征的患病率与那些脂蛋白处于后四分之一的儿童没有差异（HDL-c 的前四分之一）。在队列中前四分之一的 Apo-B/A1 比值的男孩中，BMI z 分数、腰围 z 分数、体脂百分比、舒张压和代谢综合征的频率更高（p<0.05）。在女孩中，在 Apo-B/A1 比值处于前四分之一的儿童中，腰围、体脂百分比和代谢综合征的患病率更高（p<0.05）。Apo-B/A1 比值可用于识别澳大利亚原住民儿童的心血管风险，并且由于检测方法标准化、准确、自动化，且不需要空腹样本，因此适合临床实践。
