Department of Aerospace and Mechanical Engineering, Soft Tissue Biomechanics Laboratory, University of Arizona, 1130 N Mountain Ave., PO Box 210119, Tucson, AZ 85721-0119, USA.
Ann Biomed Eng. 2010 Aug;38(8):2553-62. doi: 10.1007/s10439-010-0013-7. Epub 2010 Apr 6.
Unilateral vocal fold paralysis (UVP) results from damage to the recurrent laryngeal nerve (RLN). The most common causes of UVP are associated with compromised RLN tissue. The purpose of this research was to investigate the biomechanical properties of piglet RLN and identify differences in these properties along its length and in between the left and right side. Quasi-static uniaxial tensile testing and isotropic constitutive modeling was performed on seven piglet RLNs. Stiffness and other biomechanical parameters were derived from these tests and compared from conducting two different statistical analysis for the between and within nerve comparisons. Results showed higher stiffness values in the left RLN segment than for the right. Descriptive data demonstrated a higher stiffness in RLN segments surrounding the aortic arch, indicating a more protective role of the extracellular matrix in these nerves. This research offers insight regarding the protective function of the RLN connective tissues and structural compromise due to its environment.
单侧声带麻痹（UVP）是由喉返神经（RLN）损伤引起的。UVP 最常见的原因与 RLN 组织受损有关。本研究旨在研究仔猪 RLN 的生物力学特性，并确定其长度和左右两侧的这些特性之间的差异。对 7 个仔猪 RLN 进行准静态单轴拉伸测试和各向同性本构建模。从这些测试中得出了刚度和其他生物力学参数，并通过对神经之间和神经内部的比较进行了两种不同的统计分析来比较这些参数。结果表明，左侧 RLN 段的刚度值高于右侧。描述性数据表明，在主动脉弓周围的 RLN 段有更高的刚度，这表明细胞外基质在这些神经中起到了更具保护性的作用。这项研究提供了有关 RLN 结缔组织的保护功能以及由于其环境导致的结构损伤的见解。
