The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
Med Mycol. 2010 May;48(3):506-10. doi: 10.3109/13693780903225813.
The pathogenicity of six mutants of Aspergillus fumigatus that had been previously characterized in mice was assessed in Toll-deficient Drosophila melanogaster flies. Four out of six mutants of A. fumigatus, which displayed attenuated virulence in mice due to defects in siderophore biosynthesis (DeltasidA, DeltasidD), PABA metabolism (H515), and starvation stress response (DeltacpcA), also had attenuated virulence in the fly model. In addition, similarly to previous findings in the mouse model, DeltasidG mutant that is defective in extracellular siderophore biosynthesis retained full virulence in Toll-deficient flies. Overall, our studies reveal a high level of concordance between fly and murine models of invasive aspergillosis.
先前在小鼠中鉴定的 6 种烟曲霉突变体的致病性在 Toll 缺陷型黑腹果蝇中进行了评估。6 种烟曲霉突变体中的 4 种由于铁载体生物合成缺陷（DeltasidA、DeltasidD）、PABA 代谢缺陷（H515）和饥饿应激反应缺陷（DeltacpcA），在小鼠中的毒力减弱，在果蝇模型中也表现出毒力减弱。此外，与在小鼠模型中的先前发现相似，缺陷于细胞外铁载体生物合成的 DeltasidG 突变体在 Toll 缺陷型果蝇中保持完全毒力。总体而言，我们的研究揭示了侵袭性曲霉病的果蝇和小鼠模型之间具有高度一致性。
Zotero 插件