Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University Hospital, Uppsala, Sweden.
Ups J Med Sci. 2010 May;115(2):81-7. doi: 10.3109/03009730903518480.
This paper deals with aneurysmal disease, primarily when localized in the abdominal aorta. It is based on the Olof Rudbeck lecture 2009. Aneurysm is a localized widening of an artery, and its definition has become an important issue today when the disease is in focus for screening programmes. Aetiology and pathogenesis are still poorly understood, but a genetic component determining the strength of the aortic wall is important, and there is a strong male dominance. Historically, several attempts have been made to treat the disease, but reconstructive treatment has been possible only since 1951, in an increasing number of cases performed endovascularly. By early detection through screening, and thereby the possibility to treat before rupture, it has now become possible to decrease the total mortality from the disease in the population.
本文主要讨论了腹主动脉局部的动脉瘤疾病。这是基于 2009 年 Olof Rudbeck 讲座的内容。动脉瘤是动脉的局部扩张，其定义在当今疾病成为筛查计划的重点时变得非常重要。病因和发病机制仍知之甚少，但决定主动脉壁强度的遗传因素很重要，而且男性占主导地位。从历史上看，人们曾多次尝试治疗这种疾病，但自 1951 年以来，只有在越来越多的情况下才能进行血管内重建治疗。通过早期筛查发现，并在破裂前进行治疗，现在已经有可能降低人群中该疾病的总死亡率。
