基于甲基纤维素贴片的傅里叶变换红外光谱特征与酒石酸美托洛尔释放的相关性。

Correlation between the FT-IR characteristics and metoprolol tartrate release of methylcellulose-based patches.

机构信息

Semmelweis University, School of PhD Studies, Budapest, Hungary.

出版信息

Int J Pharm. 2010 Jun 15;392(1-2):189-91. doi: 10.1016/j.ijpharm.2010.03.053. Epub 2010 Apr 3.

DOI:10.1016/j.ijpharm.2010.03.053

PMID:20371276

Abstract

The aim of the present study was to investigate how the drug release and FT-IR characteristics of metolose patches were influenced by the changes of Metolose SM 4000 (methylcellulose) and Metolose 90SH 100.000SR (hypromellose) proportions. FT-IR spectroscopy measurements were performed in parallel with the metoprolol tartrate release study to track the effect of the composition on the drug release. The metoprolol tartrate release profile of the patches was evaluated by Weibull distribution. Linear relationship was found with good correlation between the logarithm of time interval necessary to release 63.2% of metoprolol tartrate (tau(d) values) and the peak area measured within the characteristic FT-IR wavenumbers of patches. The application of FT-IR measurements can be recommended as a rapid, non-destructive screening method during the in-process control of patches.

摘要

本研究旨在探讨药物释放和傅里叶变换红外（FT-IR）特征如何受甲氧基聚乙二醇 4000（甲基纤维素）和羟丙甲纤维素 90SH 100.000SR（羟丙甲纤维素）比例变化的影响。FT-IR 光谱测量与酒石酸美托洛尔的释放研究同时进行，以跟踪组成对药物释放的影响。用 Weibull 分布评估酒石酸美托洛尔贴片的释放曲线。发现对数时间间隔与在贴片特征 FT-IR 波数范围内测量的峰面积之间存在线性关系，该时间间隔是释放 63.2%酒石酸美托洛尔所需的时间（tau(d) 值）。FT-IR 测量的应用可以作为贴片过程控制中的一种快速、无损的筛选方法。