通过化学手段诱导 CD8+T 细胞记忆：化学生物学带来更好的生活。
Pharmacologic induction of CD8+ T cell memory: better living through chemistry.
机构信息
Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Sci Transl Med. 2009 Dec 16;1(11):11ps12. doi: 10.1126/scitranslmed.3000302.
Abstract
The generation of a robust population of memory T cells is critical for effective vaccine and cell-based therapies to prevent and treat infectious diseases and cancer. A series of recent papers have established a new, cell-intrinsic approach in which small molecules target key metabolic and developmental pathways to enhance the formation and maintenance of highly functional CD8(+) memory T cells. These findings raise the exciting new possibility of using small molecules, many of which are already approved for human use, for the pharmacologic induction of immunologic memory.
摘要
产生大量记忆 T 细胞对于有效预防和治疗传染病和癌症的疫苗和细胞疗法至关重要。最近的一系列论文确立了一种新的、细胞内在的方法，即小分子靶向关键代谢和发育途径，以增强高度功能性 CD8(+)记忆 T 细胞的形成和维持。这些发现提出了一个令人兴奋的新可能性，即使用小分子（其中许多已被批准用于人类）进行药理学诱导免疫记忆。
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