Center for Paediatrics, Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany.
Chest. 2010 Apr;137(4):909-15. doi: 10.1378/chest.09-1554.
Asthma is a complex syndrome leading to the easily recognizable clinical feature of wheezing. This is believed to be caused by inflammation, constriction of the airway smooth muscles, and extensive mucus secretion. However, the mechanisms initiating and maintaining these simple clinical features are not well understood, even after 100 years of asthma research. Still worse is our understanding of why certain individuals develop asthma and others do not.
哮喘是一种复杂的综合征，导致容易识别的喘息临床特征。据信，这是由炎症、气道平滑肌收缩和广泛的粘液分泌引起的。然而，即使在哮喘研究 100 年后，引发和维持这些简单临床特征的机制仍未得到很好的理解。更糟糕的是，我们对为什么某些人会患上哮喘而另一些人不会的原因了解甚少。
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