Department of Respiratory Medicine, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
Immunogenetics. 2011 Jan;63(1):23-32. doi: 10.1007/s00251-010-0489-1. Epub 2010 Nov 16.
The -159C/T polymorphism in the CD14 gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the -159C/T polymorphism in the CD14 gene and the risk of asthma by meta-analysis. We searched Pubmed, Embase, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on April 20, 2010). Statistical analysis was performed by using the softwares Revman 4.2 and STATA 10.0. A total of 17 case-control studies in 17 articles (4,246 cases and 3,631 controls) were included in this meta-analysis. There was no association between this polymorphism and asthma risk in combined analyses (odds ratio (OR) = 0.86 and 95% confidence interval (95% CI) = 0.72-1.02, P = 0.09 for TC + TT vs. CC). In the subgroup analysis by age, ethnicity, and atopic status, no significant associations of asthma risks were obtained from age groups, ethnic groups, and atopic groups for TC + TT vs. CC comparison. For atopic population, significant decreased atopic asthma risks were found among Asian population (OR = 0.69, 95% CI 0.52-0.92, P = 0.01) and children population (OR = 0.69, 95% CI 0.54-0.89, P = 0.0004) for TC + TT vs. CC comparison. This meta-analysis suggests that CD14 is a candidate gene for atopic asthma susceptibility. The -159C/T polymorphism may be a protective factor for atopic asthma in Asian and children. More studies are needed to validate these associations.
CD14 基因-159C/T 多态性与哮喘易感性有关，但大量研究结果尚无定论。本研究旨在通过荟萃分析探讨 CD14 基因-159C/T 多态性与哮喘发病风险的关系。我们检索了 Pubmed、Embase、中国知网（CNKI）数据库、万方数据库、维普数据库和中国生物医学文献数据库，检索时间截至 2010 年 4 月 20 日。采用 Revman 4.2 和 STATA 10.0 软件进行统计学分析。共纳入 17 项研究的 17 个病例对照研究（4246 例病例和 3631 例对照）。合并分析结果显示，该多态性与哮喘发病风险无关（比值比（OR）=0.86，95%可信区间（95%CI）=0.72-1.02，P=0.09）。按年龄、种族和特应性状态进行亚组分析，未发现 TC+TT 与 CC 比较在年龄组、种族组和特应性组中与哮喘发病风险有显著相关性。在特应性人群中，亚洲人群（OR=0.69，95%CI 0.52-0.92，P=0.01）和儿童人群（OR=0.69，95%CI 0.54-0.89，P=0.0004）中 TC+TT 与 CC 比较，特应性哮喘发病风险显著降低。本荟萃分析提示 CD14 是特应性哮喘的候选易感基因。-159C/T 多态性可能是亚洲人和儿童特应性哮喘的保护性因素。还需要更多的研究来验证这些关联。
