Department of Animal Science, National Chiayi University 600, Taiwan.
Poult Sci. 2010 May;89(5):924-30. doi: 10.3382/ps.2009-00239.
This study investigated effects of caponization and different forms of androgen implantation on blood lipid and lipoprotein profile of capons to understand the role of different androgens. Male chickens were caponized at 12 wk of age and selected at 16 wk of age for a 10-wk feeding period. Sixteen intact caponized (capon) male chickens and 16 female chickens were assigned for trial 1, and 16 sham-operated (sham) male chickens and 64 capons were selected for trial 2, in which capons were randomly divided into cholesterol (CHOL), testosterone (TES), 5alpha-dihydrotestosterone, or 19-nortestosterone (19-NorT) implantation at 16, 20, and 24 wk of age. Trial 1 showed that caponization decreased TES concentration (P < 0.05) in male chickens while showing no difference with females (P > 0.05). Caponization increased lipoprotein lipase (LPL) activity and relative abdominal fat weight (P < 0.05) to a level compatible with females (P > 0.05). Caponization also increased low-density lipoprotein (LDL) content and LDL-protein percentage (P < 0.05) but decreased high-density lipoprotein-free CHOL percentage (P < 0.05) compared with intact males. In trial 2, androgen implantation showed lower relative abdominal fat weight (P < 0.05) than CHOL. Only 19-NorT reached a level compatible with the sham (P > 0.05). Cholesterol implantation increased LPL activity compared with the sham (P < 0.05), and 19-NorT and 5alpha-dihydrotestosterone showed the lowest LPL activity (P < 0.05). Different androgen implantations increased LDL and very low density lipoprotein + LDL ratios and decreased high-density lipoprotein ratio (P < 0.05) to the compatible level with the sham (P > 0.05). Different levels of androgen implantation also demonstrated changes in LDL triacylglyceride and protein percentage and reached a level compatible with the sham (P > 0.05). Caponization decreased blood TES concentration in male chickens, increased LPL activity, and changed the lipoprotein composition, leading to an increase in abdominal fat weight. Results of different androgen implantations in capons demonstrated no difference in lipoprotein profile between androgens, but 19-NorT performed most effectively in abdominal fat accumulation recovery.
本研究旨在探讨去势和不同形式雄激素植入对阉鸡血脂和脂蛋白谱的影响，以了解不同雄激素的作用。雄性鸡在 12 周龄时去势，并在 16 周龄时选择进行 10 周的饲养期。16 只去势的完整阉鸡（阉鸡）雄性鸡和 16 只母鸡被分配进行试验 1，16 只假手术（假手术）雄性鸡和 64 只阉鸡被选择进行试验 2，其中阉鸡在 16、20 和 24 周龄时随机分为胆固醇（CHOL）、睾丸酮（TES）、5α-二氢睾丸酮或 19-去甲睾丸酮（19-NorT）植入组。试验 1 表明，去势降低了雄性鸡的 TES 浓度（P<0.05），而与雌性鸡无差异（P>0.05）。去势增加了脂蛋白脂肪酶（LPL）活性和相对腹部脂肪重量（P<0.05），达到与雌性鸡相同的水平（P>0.05）。与完整雄性鸡相比，去势还增加了低密度脂蛋白（LDL）含量和 LDL-蛋白百分比（P<0.05），但降低了高密度脂蛋白无胆固醇百分比（P<0.05）。在试验 2 中，雄激素植入显示相对腹部脂肪重量低于 CHOL（P<0.05）。只有 19-NorT 达到与假手术相同的水平（P>0.05）。胆固醇植入与假手术相比增加了 LPL 活性（P<0.05），而 19-NorT 和 5α-二氢睾丸酮显示出最低的 LPL 活性（P<0.05）。不同的雄激素植入增加了 LDL 和极低密度脂蛋白+LDL 比值，并降低了高密度脂蛋白比值（P<0.05），达到与假手术相同的水平（P>0.05）。不同水平的雄激素植入也改变了 LDL 三酰甘油和蛋白质百分比，并达到与假手术相同的水平（P>0.05）。去势降低了雄性鸡的血液 TES 浓度，增加了 LPL 活性，并改变了脂蛋白组成，导致腹部脂肪重量增加。不同雄激素植入在阉鸡中的结果表明，不同雄激素之间的脂蛋白谱没有差异，但 19-NorT 在腹部脂肪堆积恢复方面效果最显著。
