流鼻水是帕金森病被低估的内在症状吗？一项前瞻性初步研究。

Is rhinorrhea an under-recognized intrinsic symptom of Parkinson disease? A prospective pilot study.

机构信息

College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

出版信息

Int J Neurosci. 2010 Apr;120(4):258-60. doi: 10.3109/00207451003615755.

DOI:10.3109/00207451003615755

PMID:20374072

Abstract

PURPOSE

The purpose of this study is to compare the prevalence of idiopathic rhinorrhea in PD patients versus controls, to determine the correlation between rhinorrhea and anosmia, and the factors associated with rhinorrhea.

SCOPE

A cohort of 61 PD patients and 51 age-matched controls completed a survey about rhinorrhea and underwent the University of Pennsylvania Smell Identification Test (UPSIT). We compared the prevalence of idiopathic rhinorrhea in the PD patients versus controls, the correlation between rhinorrhea and anosmia in PD patients, and the factors associated with rhinorrhea in the PD patients. The results of the study are that 6% of controls versus 24% of PD patients had rhinorrhea (p = .03); moreover, only 2% of controls versus 15% of PD patients had severe rhinorrhea.

CONCLUSION

Rhinorrhea is more prevalent in PD patients compared to controls and it does not significantly impact performance on a smell test.

摘要

目的

本研究旨在比较 PD 患者与对照组中特发性鼻溢的患病率，确定鼻溢与嗅觉丧失之间的相关性，以及与鼻溢相关的因素。

范围

本研究纳入了 61 名 PD 患者和 51 名年龄匹配的对照组，他们完成了一项关于鼻溢的调查，并接受了宾夕法尼亚大学嗅觉识别测试（UPSIT）。我们比较了 PD 患者与对照组中特发性鼻溢的患病率、PD 患者中鼻溢与嗅觉丧失之间的相关性，以及与 PD 患者鼻溢相关的因素。研究结果显示，对照组中 6%的人有鼻溢，而 PD 患者中 24%的人有鼻溢（p=0.03）；此外，对照组中只有 2%的人有严重的鼻溢，而 PD 患者中有 15%的人有严重的鼻溢。