Department of Psychology, University of Bern, Bern, Switzerland.
Int J Neurosci. 2010 Mar;120(3):211-6. doi: 10.3109/00207450903506510.
There is conflicting evidence whether Parkinson's disease (PD) is associated with impaired recognition memory and which of its underlying processes, namely recollection and familiarity, is more affected by the disease. The present study explored the contribution of recollection and familiarity to verbal recognition memory performance in 14 nondemented PD patients and a healthy control group with two different methods: (i) the word-frequency mirror effect, and (ii) Remember/Know judgments. Overall, recognition memory of patients was intact. The word-frequency mirror effect was observed both in patients and controls: Hit rates were higher and false alarm rates were lower for low-frequency compared to high-frequency words. However, Remember/Know judgments indicated normal recollection, but impaired familiarity. Our findings suggest that mild to moderate PD patients are selectively impaired at familiarity whereas recollection and overall recognition memory are intact.
是否帕金森病（PD）与识别记忆受损有关，以及其潜在过程中的哪一个（即回忆和熟悉度）受疾病影响更大，这方面存在相互矛盾的证据。本研究使用两种不同方法探索了回忆和熟悉度对 14 名非痴呆 PD 患者和健康对照组的言语识别记忆表现的贡献：（i）单词频率镜像效应，和（ii）记住/知道判断。总的来说，患者的识别记忆是完整的。单词频率镜像效应在患者和对照组中均观察到：与高频词相比，低频词的击中率更高，虚报率更低。然而，记住/知道判断表明回忆正常，但熟悉度受损。我们的研究结果表明，轻度至中度 PD 患者在熟悉度方面选择性受损，而回忆和整体识别记忆则完好无损。
