Department of Nephrology, Baskent University Hospital, Ankara, Turkey.
Clin Exp Hypertens. 2010 Jan;32(2):105-12. doi: 10.3109/10641960902993137.
Hypertensive patients report lower general well-being, more severe psychological distress, poorer perceived health status, more physical symptoms, and functional disability when compared to normotensive patients. Nondipping of blood pressure (BP) is related to increased target organ damage in essential hypertension. However, the specific relationship between nocturnal nondipping and quality of life has not been extensively investigated. Patients with essential hypertension underwent the following procedures: anamnesis, office BP measurement, physical examination, routine biochemistry, and 24-hour ambulatory BP monitoring. To determine renal function, 24-hour urine specimens were collected. Quality of life was assessed by a short form of medical outcomes study (SF-36). Totally, 132 patients (male/female: 55/75) were included. Fifty-five of the patients were nondippers. The dippers and nondippers were not statistically different in terms of socio-demographic parameters. Dippers had higher physical functioning (P- 0.004), bodily pain (P- 0.008), and PCS (P - 0.003) than nondippers. PCS of SF-36 was independently associated with age (P - 0.029), body mass index (P - 0.022), presence of coronary artery disease (P - 0.01), gender (P - 0.009), and dipping phenomenon (P - 0.006). A mental component summary score of SF-36 was not associated with dipping phenomenon. Nocturnal nondipping, apart from having important prognostic implications for cardiovascular complications in essential hypertensive patients, is also related to quality of life, especially in its physical aspects.
与正常血压患者相比，高血压患者报告整体健康状况较差、心理困扰更严重、健康状况感知更差、身体症状更多、功能障碍更多。非杓型血压（BP）与原发性高血压的靶器官损害增加有关。然而，夜间非杓型与生活质量之间的具体关系尚未得到广泛研究。原发性高血压患者接受了以下程序：病史、诊室血压测量、体格检查、常规生化检查和 24 小时动态血压监测。为了确定肾功能，收集了 24 小时尿液标本。通过医疗结局研究（SF-36）的简短形式评估生活质量。总共纳入了 132 名患者（男/女：55/75）。其中 55 名患者是非杓型。杓型和非杓型患者在社会人口统计学参数方面无统计学差异。杓型患者的身体机能（P-0.004）、身体疼痛（P-0.008）和 PCS（P-0.003）更高。SF-36 的 PCS 与年龄（P-0.029）、体重指数（P-0.022）、冠状动脉疾病（P-0.01）、性别（P-0.009）和杓型现象（P-0.006）独立相关。SF-36 的心理成分综合评分与杓型现象无关。除了对原发性高血压患者心血管并发症具有重要预后意义外，夜间非杓型还与生活质量相关，尤其是在身体方面。
