Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Israel.
Basic Clin Pharmacol Toxicol. 2010 Sep;107(3):737-41. doi: 10.1111/j.1742-7843.2010.00569.x. Epub 2010 Mar 31.
Acute iron intoxication is one of the leading causes of overdose morbidity and mortality in children. The toxicity of iron has been postulated to be related to free radical formation and subsequent lipid peroxidation. Hyperbaric oxygen treatment can result in a number of beneficial biochemical, cellular and physiological effects, and has recently been shown to induce cellular protection against ischaemia, and in some cases against free radical formation. In the current study, we aimed to investigate the effects of hyperbaric oxygen treatment on mortality in acute iron intoxication in rats. After iron administration, 57 animals were divided into two groups: a treatment group receiving hyperbaric oxygen treatment (n = 30) and a control group (n = 27), and followed for 48 hr for signs of severe intoxication. In the second part of the study, 21 animals were divided into a treatment group receiving hyperbaric oxygen treatment (n = 10) and a control group (n = 11), and markers of oxidative stress were evaluated. We showed a significant reduction in mortality in hyperbaric oxygen-treated animals from 17 of 27 (62.9%) among untreated rats to 6 of 30 (20%). Surprisingly, in the treatment group, levels of oxidative stress markers were higher. We postulate that hyperbaric oxygen has a potentially beneficial effect in acute iron intoxication.
急性铁中毒是导致儿童过量用药发病率和死亡率的主要原因之一。铁的毒性据推测与自由基形成和随后的脂质过氧化有关。高压氧治疗可产生许多有益的生化、细胞和生理效应，最近已被证明可诱导细胞对缺血和在某些情况下对自由基形成的保护。在本研究中，我们旨在研究高压氧治疗对急性铁中毒大鼠死亡率的影响。铁给药后，57 只动物分为两组：高压氧治疗组（n = 30）和对照组（n = 27），并在 48 小时内观察严重中毒的迹象。在研究的第二部分，21 只动物分为高压氧治疗组（n = 10）和对照组（n = 11），并评估氧化应激标志物。我们发现，与未治疗的大鼠相比，接受高压氧治疗的动物死亡率从 27 只中的 17 只（62.9%）显著降低至 30 只中的 6 只（20%）。令人惊讶的是，在治疗组中，氧化应激标志物的水平更高。我们推测高压氧对急性铁中毒具有潜在的有益作用。
