Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Am Geriatr Soc. 2010 Feb;58(2):265-74. doi: 10.1111/j.1532-5415.2009.02679.x. Epub 2010 Jan 26.
To better understand how brain atrophy in amnestic mild cognitive impairment (MCI) as measured using magnetic resonance imaging (MRI) volumetrics could affect instrumental activities of daily living (IADLs) such as financial abilities.
Controlled, matched-sample, cross-sectional analysis regressing MRI volumetrics with financial performance measures.
University medical and research center.
Thirty-eight people with MCI and 28 older adult controls.
MRI volumetric measurement of the hippocampi, angular gyri, precunei, and medial frontal lobes. Participants also completed neuropsychological tests and the Financial Capacity Instrument (FCI).
Correlations were performed between FCI scores and MRI volumes in the group with MCI. People with MCI performed significantly below controls on the FCI and had significantly smaller hippocampi. Among people with MCI, performance on the FCI was moderately correlated with angular gyri and precunei volumes. Regression models demonstrated that angular gyrus volumes were predictive of FCI scores. Tests of mediation showed that measures of arithmetic and possibly attention partially mediated the relationship between angular gyrus volume and FCI score.
Impaired financial abilities in amnestic MCI correspond with volume of the angular gyri as mediated by arithmetic knowledge. The findings suggest that early neuropathology within the lateral parietal region in MCI leads to a breakdown of cognitive abilities that affect everyday financial skills. The findings have implications for diagnosis and clinical care of people with MCI and AD.
更好地理解磁共振成像（MRI）体积测量法所测遗忘型轻度认知障碍（MCI）患者的脑萎缩如何影响工具性日常生活活动（IADLs），如财务能力。
对照、匹配样本、横截面分析，用 MRI 体积衡量法来预测财务表现的测量值。
大学医学和研究中心。
38 名 MCI 患者和 28 名老年对照组。
MRI 对海马体、角回、楔前叶和内侧额叶的体积测量。参与者还完成了神经心理学测试和财务能力量表（FCI）。
在 MCI 组中进行了 FCI 分数与 MRI 体积之间的相关性分析。MCI 患者在 FCI 上的表现明显低于对照组，且海马体明显较小。在 MCI 患者中，FCI 的表现与角回和楔前叶的体积呈中度相关。回归模型表明，角回的体积可以预测 FCI 评分。中介测试表明，算术和可能注意力的测量部分中介了角回体积和 FCI 评分之间的关系。
遗忘型 MCI 患者的财务能力受损与角回的体积有关，这与算术知识有关。这些发现表明，MCI 患者外侧顶叶区域的早期神经病理学导致认知能力下降，从而影响日常的财务技能。这些发现对 MCI 和 AD 患者的诊断和临床护理具有重要意义。
