先天免疫是否通过不同途径进化而来？

Has innate immunity evolved through different routes?

机构信息

Dipartimento di Biologia Animale, Università di Palermo, Via Archirafi 18, 9123 Palermo, Italy.

出版信息

Phys Life Rev. 2010 Mar;7(1):83-4; discussion 85-7. doi: 10.1016/j.plrev.2010.01.007. Epub 2010 Jan 14.

DOI:10.1016/j.plrev.2010.01.007

PMID:20374931

Abstract

Invertebrate self/non-self recognition, defense responses, mating and development share innate immune surveillance and functions challenged by competition and linked to fitness. Independent evolutionary branches of immune responses may use conserved gene traits. On the other hand immunity genes may be conserved due to their role in development. Finally, upregulation of innate immunity genes during ascidian metamorphosis supports the danger hypothesis.

摘要

无脊椎动物的自我/非我识别、防御反应、交配和发育共享先天免疫监视和功能，这些功能受到竞争的挑战，并与适应性相关。免疫反应的独立进化分支可能使用保守的基因特征。另一方面，由于免疫基因在发育中的作用，它们可能是保守的。最后，在海鞘变态过程中先天免疫基因的上调支持了危险假说。