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颅内动脉瘤性蛛网膜下腔出血后认知主诉的发生率及决定因素。

Prevalence and determinants of cognitive complaints after aneurysmal subarachnoid hemorrhage.

机构信息

Department of Rehabilitation, Nursing Science and Sports, Rudolf Magnus Institute for Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.

出版信息

Cerebrovasc Dis. 2010;29(6):557-63. doi: 10.1159/000306642. Epub 2010 Apr 8.

DOI:10.1159/000306642
PMID:20375498
Abstract

BACKGROUND

To investigate the prevalence of cognitive complaints after subarachnoid hemorrhage (SAH) and the relationships between cognitive complaints and cognitive impairments, disability and emotional problems.

METHODS

Cognitive complaints were assessed with the Checklist for Cognitive and Emotional Consequences following stroke (CLCE-24) in 111 persons who visited our outpatient clinic 3 months after SAH. Associations between cognitive complaints and cognitive functioning, demographic characteristics, disability and emotional problems were examined using Spearman correlations and linear regression analysis.

RESULTS

In this study group, 105 patients (94.6%) reported at least one cognitive or emotional complaint that hampered everyday functioning. The most frequently reported cognitive complaints were mental slowness, short-term memory problems and attention deficits. All cognitive domains, disability, depressive symptoms and feelings of anxiety were significantly associated with the CLCE-24 cognition score. In the final regression model, memory functioning (beta value -0.21), disability (-0.28) and depressive symptoms (0.40) were significant determinants of cognitive complaints, together explaining 35.4% of the variance.

CONCLUSION

Cognitive complaints are common after SAH and associated with memory deficits, disability and depressive symptoms. Rehabilitation programs should focus on these symptoms and deficits.

摘要

背景

调查蛛网膜下腔出血(SAH)后认知主诉的发生率,以及认知主诉与认知障碍、残疾和情绪问题之间的关系。

方法

在 SAH 后 3 个月,111 名患者到我院门诊就诊,使用卒中后认知和情绪后果清单(CLCE-24)评估认知主诉。采用 Spearman 相关分析和线性回归分析,检验认知主诉与认知功能、人口统计学特征、残疾和情绪问题之间的关系。

结果

在本研究组中,105 例患者(94.6%)报告至少有一种认知或情绪主诉,这些主诉妨碍了日常功能。最常报告的认知主诉是思维迟钝、短期记忆问题和注意力缺陷。所有认知域、残疾、抑郁症状和焦虑感均与 CLCE-24 认知评分显著相关。在最终的回归模型中,记忆功能(β值-0.21)、残疾(-0.28)和抑郁症状(0.40)是认知主诉的显著决定因素,共解释了 35.4%的方差。

结论

蛛网膜下腔出血后常出现认知主诉,且与记忆障碍、残疾和抑郁症状有关。康复计划应关注这些症状和缺陷。

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