Leombruni Paolo, Gastaldi Filippo
Department of Neuroscience, Centre for Eating Disorders, Turin University, Turin, Italy.
Clin Neuropharmacol. 2010 Mar-Apr;33(2):107-8. doi: 10.1097/WNF.0b013e3181c8764f.
There is no pharmacological treatment of trichotillomania that has consistently demonstrated efficacy, although good results have been obtained with antidepressants and other drugs such as atypical antipsychotics, bupropion, lithium, and topiramate. The anticonvulsant oxcarbazepine has also been used as mood stabilizer and has been tested for treating binge eating, but there is no report on oxcarbazepine in trichotillomania.
We report the case of an obese 43-year-old woman with a diagnosis of trichotillomania in comorbidity with binge eating disorder who was treated with a flexible dose of the anticonvulsant oxcarbazepine.
We administered oxcarbazepine at a dosage of 1200 mg/d, and this subject improved both in hair pulling and in eating behaviors with no relapse after 9 months.
Further studies with a wide sample of patients are needed to prove the efficacy of oxcarbazepine and the long-term maintenance of these benefits. Relationships of trichotillomania with bipolar spectrum should also be investigated.
尽管使用抗抑郁药及其他药物（如非典型抗精神病药、安非他酮、锂盐和托吡酯）已取得良好效果，但尚无一直证明有效的拔毛癖药物治疗方法。抗惊厥药奥卡西平也已用作情绪稳定剂，并已进行治疗暴饮暴食的试验，但尚无关于奥卡西平治疗拔毛癖的报告。
我们报告一例43岁肥胖女性病例，诊断为拔毛癖合并暴饮暴食症，接受了灵活剂量的抗惊厥药奥卡西平治疗。
我们给予奥卡西平剂量为1200毫克/天，该患者的拔毛行为和饮食行为均有改善，9个月后无复发。
需要对大量患者样本进行进一步研究，以证明奥卡西平的疗效以及这些益处的长期维持情况。还应研究拔毛癖与双相谱系的关系。
