Department of Molecular Biology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 5 W.K. Roentgena, 02-781 Warsaw, Poland.
Int J Gynecol Cancer. 2010 Apr;20(3):434-7. doi: 10.1111/IGC.0b013e3181d320f1.
Vulvar cancer is a rare condition representing about 4% of all female genital tract tumors. In contrast to the established relationship of virtually all cervical cancer cases with the human papillomavirus (HPV) infection, the reported HPV positivity in vulvar carcinoma ranges widely.
Using the Linear Array HPV Genotyping Test, we investigated the HPV incidence in a group of 46 Polish patients with vulvar squamous cell carcinoma (age range, 37-93 years; median age, 70.2 years) in clinical stages T1-2, N0-2, and M0.
The presence of HPV DNA was confirmed in 7 of 46 (15%) primary tumor samples. HPV 16 was found in 5 tumors (71%). HPVs 6 and 58 were detected in the remaining 2 cases of virus-associated tumors.
We conclude that a fraction of cancers of vulva associated with HPV is insignificant, given the HPV prevalence of 8.6% in the Polish population aged 55 to 59 years (the oldest cohort of Polish women studied to date).
外阴癌是一种罕见的疾病，占女性生殖道肿瘤的 4%左右。与几乎所有宫颈癌病例与人类乳头瘤病毒（HPV）感染的明确关系形成对比的是，报告的外阴癌中 HPV 阳性率差异很大。
我们使用线性阵列 HPV 基因分型检测，对 46 名波兰外阴鳞状细胞癌患者（年龄 37-93 岁，中位年龄 70.2 岁）的 HPV 发病率进行了研究，这些患者处于 T1-2、N0-2 和 M0 临床分期。
在 46 个原发性肿瘤样本中，有 7 个（15%）证实存在 HPV DNA。在 5 个肿瘤中发现了 HPV 16（71%）。在另外 2 例与病毒相关的肿瘤中检测到了 HPV 6 和 58。
我们的结论是，考虑到在 55 至 59 岁的波兰人群（迄今为止研究的最年长的波兰女性队列）中 HPV 的流行率为 8.6%，与 HPV 相关的外阴癌的一小部分并不显著。
