人乳头瘤病毒在外阴鳞状细胞癌、各种同步上皮变化及正常外阴皮肤中的感染情况。
Human papillomavirus infection in squamous cell carcinoma of the vulva, in various synchronous epithelial changes and in normal vulvar skin.
作者信息
Kagie M J, Kenter G G, Zomerdijk-Nooijen Y, Hermans J, Schuuring E, Timmers P J, Trimbos J B, Fleuren G J
机构信息
Department of Gynecology, Leiden University Medical Center, The Hague, 2501 CK, The Netherlands.
出版信息
Gynecol Oncol. 1997 Nov;67(2):178-83. doi: 10.1006/gyno.1997.4834.
OBJECTIVE
To investigate the prevalence of human papillomavirus (HPV) infection in various vulvar lesions.
METHODS
HPV infection using consensus primer-PCR was studied in 66 patients with vulvar carcinoma and in the synchronous epithelial lesions.
RESULTS
HPV infection was present in 13/66 carcinoma, in 1/33 VIN I, in 3/11 VIN II, in 8/16 VIN III, in 2/30 lichen sclerosus, in 1/37 squamous cell hyperplasia, and in 2/55 normal skin specimens. Normal skin from healthy controls showed HPV-negative specimens only. Patients with HPV-positive carcinomas were younger, presented in lower stages, and had high-grade VIN more often than those with HPV-negative carcinomas.
CONCLUSIONS
In sum we found that all types of epithelial changes synchronous with carcinoma of the vulva showed HPV infection, indicating that they all might have malignant potential.
目的
研究各种外阴病变中人类乳头瘤病毒（HPV）感染的患病率。
方法
采用共识引物聚合酶链反应（PCR）对66例外阴癌患者及其同步上皮病变中的HPV感染情况进行研究。
结果
66例癌组织中有13例存在HPV感染，33例VIN I中有1例，11例VIN II中有3例，16例VIN III中有8例，30例硬化性苔藓中有2例，37例鳞状上皮增生中有1例，55例正常皮肤标本中有2例。健康对照的正常皮肤标本均显示HPV阴性。HPV阳性癌患者比HPV阴性癌患者更年轻，分期更低，且高级别VIN更为常见。
结论
总之，我们发现与外阴癌同步的所有类型上皮变化均显示HPV感染，表明它们都可能具有恶性潜能。
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