Rastan Ardawan Julian, Thiele Holger, Schuler Gerhard, Mohr Friedrich Wilhelm
Klinik für Herzchirurgie, Universität Leipzig, Herzzentrum Leipzig, Leipzig, Germany.
Herz. 2010 Mar;35(2):70-8. doi: 10.1007/s00059-010-3327-1.
According to the current guidelines coronary revascularization in acute coronary syndromes (ACS) is primarily performed by percutaneous coronary interventions (PCI). However, in several scenarios like complex coronary pathologies, unsuccessful PCI, complicated PCI or cardiogenic shock, surgical coronary revascularization might be indicated. Then, timing of the operation is based on clinical symptoms, coronary artery pathology, and the type of underlying ACS (Figure 1). Surgical strategies among others include the use of beating-heart strategies. Furthermore, a modern perioperative management allows improved results in a more aged and comorbid patient population as well as in patients presenting with hemodynamic instability. In cardiogenic shock, a variety of different cardiopulmonary assist devices are available today including intra-aortic balloon pump, several ventricular assist devices, and extracorporeal membrane oxygenation (Figure 2).In the literature, results of coronary artery bypass grafting (CABG) in ACS patients vary significantly because of different patient populations, different timing of the operation, and different hemodynamic status. Thus, comparison of surgical concepts is almost impossible. Until today, randomized surgical trials for ACS patients are pending. However, hospital survival of > 95% is reported even in emergency CABG patients during the last 5 years (Table 1). For all surgical candidates a close and direct communication between interventionalist and cardiac surgeon is mandatory to early identify the best treatment strategy and to achieve best possible revascularization results.
根据当前指南,急性冠脉综合征(ACS)的冠状动脉血运重建主要通过经皮冠状动脉介入治疗(PCI)进行。然而,在一些情况下,如复杂冠状动脉病变、PCI失败、PCI并发症或心源性休克,可能需要进行外科冠状动脉血运重建。此时,手术时机基于临床症状、冠状动脉病变以及潜在ACS的类型(图1)。外科策略包括采用心脏不停跳策略等。此外,现代围手术期管理能够在年龄更大、合并症更多的患者群体以及存在血流动力学不稳定的患者中取得更好的结果。在心源性休克中,如今有多种不同的心肺辅助设备可供使用,包括主动脉内球囊反搏、几种心室辅助设备以及体外膜肺氧合(图2)。在文献中,由于患者群体不同、手术时机不同以及血流动力学状态不同,ACS患者冠状动脉旁路移植术(CABG)的结果差异很大。因此,几乎无法比较不同的手术理念。直到如今,针对ACS患者的随机外科试验仍未进行。然而,在过去5年中,即使是急诊CABG患者,其院内生存率也报告超过了95%(表1)。对于所有手术候选者,介入专家与心脏外科医生之间密切而直接的沟通是必要的,以便早期确定最佳治疗策略并实现尽可能好的血运重建效果。