两例老年男性因噻氯匹定引起的迟发性药物性红斑狼疮。
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.
机构信息
Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
出版信息
Mod Rheumatol. 2010 Aug;20(4):405-9. doi: 10.1007/s10165-010-0289-3. Epub 2010 Apr 8.
We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.
在过去三年中，我们遇到了两例由噻氯匹定引起的药物性狼疮。这两例都是老年男性（76 岁和 81 岁）的迟发性病例（1 年和 4 年后发病）。共同特征是发热、关节痛、肌痛、浆膜炎和存在抗组蛋白自身抗体。由于噻氯匹定在患有缺血性血管疾病的老年人中广泛使用，因此当服用噻氯匹定的患者出现狼疮样症状时，应考虑噻氯匹定引起的狼疮。
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