Klion A D, Massougbodji A, Sadeler B C, Ottesen E A, Nutman T B
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
J Infect Dis. 1991 Jun;163(6):1318-25. doi: 10.1093/infdis/163.6.1318.
To define the clinical spectrum of loiasis more precisely and to begin to assess the immunologic basis for the difference in clinical manifestations between visitors to endemic areas and natives of these areas, 51 West African patients with loiasis were evaluated and compared with 42 infected expatriates. Microfilaremia was present in 90% and Calabar swellings in only 16% of the endemic patients. Conversely, only 10% of the expatriates were microfilaremic while 95% complained of Calabar swellings. The endemic population showed significantly decreased levels of peripheral blood eosinophils, parasite-specific IgG, and lymphocyte proliferation to parasite antigens compared with the nonendemic population. These findings support the hypothesis that differences in the modulation of the immune response to parasite antigen are responsible for the observed differences in clinical presentation between expatriate and endemic populations with loiasis.
为了更精确地界定罗阿丝虫病的临床范围，并开始评估流行地区的外来访客与当地居民临床表现差异的免疫基础，我们对51例西非罗阿丝虫病患者进行了评估，并与42例受感染的 expatriates 进行了比较。流行地区患者中90% 有微丝蚴血症，仅有16% 有卡拉巴肿。相反，expatriates 中只有10% 有微丝蚴血症，而95% 主诉有卡拉巴肿。与非流行人群相比，流行人群外周血嗜酸性粒细胞、寄生虫特异性 IgG 以及寄生虫抗原刺激的淋巴细胞增殖水平显著降低。这些发现支持了以下假说：对寄生虫抗原免疫反应调节的差异导致了有罗阿丝虫病的外来人群与流行地区人群之间观察到的临床表现差异。
