EFEMP1 在宫颈癌中的表达及其与预后的关系。
The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis.
机构信息
Biomedical Engineering Center, Department of Anatomy, the Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
出版信息
Gynecol Oncol. 2010 Jun;117(3):417-22. doi: 10.1016/j.ygyno.2009.12.016. Epub 2010 Apr 7.
OBJECTIVE
The study was to explore the role of EFEMP1 protein in angiogenesis and its relationship with prognosis of cervical carcinoma.
METHODS
EFEMP1 expression was evaluated by immunohistochemistry. The microvascular density (MVD) was detected with CD34 staining, and VEGF mRNA expression was evaluated by hybridization in situ. The associations of EFEMP1 with clinicopathologic characteristics, MVD, VEGF mRNA and overall survival were studied.
RESULTS
EFEMP1 expression was positively correlated with MVD and VEGF mRNA, and its overexpression was found to be significantly associated with lymph node metastasis, vascular invasion and poor survival. Multivariate analysis showed that EFEMP1 overexpression was independently related to poor prognosis of cervical cancer.
CONCLUSIONS
EFEMP1 promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical carcinoma. The current study shows that EFEMP1 may be a useful prognostic factor for patients with cervical carcinoma.
目的
本研究旨在探讨 EFEMP1 蛋白在血管生成中的作用及其与宫颈癌预后的关系。
方法
采用免疫组织化学法检测 EFEMP1 表达，CD34 染色检测微血管密度（MVD），原位杂交法检测 VEGF mRNA 表达。分析 EFEMP1 与临床病理特征、MVD、VEGF mRNA 及总生存的关系。
结果
EFEMP1 表达与 MVD 和 VEGF mRNA 呈正相关，其过表达与淋巴结转移、血管浸润和不良预后显著相关。多因素分析显示，EFEMP1 过表达与宫颈癌不良预后独立相关。
结论
EFEMP1 促进血管生成，并与宫颈癌的淋巴结转移、血管浸润和不良预后相关。本研究表明，EFEMP1 可能是宫颈癌患者的一个有用的预后因素。
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