治疗干眼症的水溶性 PDE4 抑制剂。
Water-soluble PDE4 inhibitors for the treatment of dry eye.
机构信息
Kalypsys, Inc., 10420 Wateridge Circle, San Diego, CA 92121, United States.
出版信息
Bioorg Med Chem Lett. 2010 May 1;20(9):2928-32. doi: 10.1016/j.bmcl.2010.03.023. Epub 2010 Mar 7.
PMID:20378348
Abstract
PDE4 inhibitors have the potential to alleviate the symptoms and underlying inflammation associated with dry eye. Disclosed herein is the development of a novel series of water-soluble PDE4 inhibitors. Our studies led to the discovery of coumarin 18, which is effective in a rabbit model of dry eye and a tear secretion test in rats.
摘要
PDE4 抑制剂具有缓解干眼相关症状和潜在炎症的潜力。本文介绍了一系列新型水溶性 PDE4 抑制剂的开发。我们的研究发现了香豆素 18，它在兔干眼模型和大鼠泪液分泌试验中有效。
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