University of Amsterdam, Swammerdam Institute for Life Sciences, Section of Plant Physiology, Kruislaan 904, 1098 XH Amsterdam, The Netherlands.
J Exp Bot. 2010 Apr;61(7):1939-57. doi: 10.1093/jxb/erq073. Epub 2010 Apr 8.
The overall function of a cell is determined by its contingent of active signal transduction cascades interacting on multiple levels with metabolic pathways, cytoskeletal organization, and regulation of gene expression. Much work has been devoted to analysis of individual signalling cascades interacting with unique cellular targets. However, little is known about how cells integrate information across hierarchical signalling networks. Recent work on pollen tube growth indicates that several key signalling cascades respond to changes in cell hydrodynamics and apical volume. Combined with known effects on cytoarchitecture and signalling from other cell systems, hydrodynamics has the potential to integrate and synchronize the function of the broader signalling network in pollen tubes. This review will explore recent work on cell hydrodynamics in a variety of systems including pollen, and discuss hydrodynamic regulation of cell signalling and function including exocytosis and endocytosis, actin cytoskeleton reorganization, cell wall deposition and assembly, phospholipid and inositol polyphosphate signalling, ion flux, small G-proteins, fertilization, and self-incompatibility. The combined data support a newly emerging model of pollen tube growth.
细胞的整体功能取决于其活跃的信号转导级联的含量，这些级联在多个层次上与代谢途径、细胞骨架组织和基因表达调控相互作用。已经有大量工作致力于分析与独特细胞靶标相互作用的单个信号级联。然而，对于细胞如何跨层次信号网络整合信息知之甚少。最近关于花粉管生长的研究表明，几个关键的信号级联对细胞流体动力学和顶端体积的变化做出反应。结合其他细胞系统对细胞结构和信号的已知影响，流体动力学有可能整合和同步花粉管中更广泛的信号网络的功能。这篇综述将探讨最近在包括花粉在内的各种系统中关于细胞流体动力学的研究，并讨论细胞信号转导和功能的流体动力学调节，包括胞吐作用和胞吞作用、肌动蛋白细胞骨架重组、细胞壁沉积和组装、磷脂和肌醇多磷酸信号转导、离子通量、小 G 蛋白、受精和自交不亲和。综合数据支持花粉管生长的一个新出现的模型。
