Calò Pietro Giorgio, Tuveri Massimiliano, Pisano Giuseppe, Tatti Alberto, Medas Fabio, Donati Marcello, Nicolosi Angelo
Dipartimento di Chirurgia e Scienze Odontostomatologiche, Università degli Studi di Cagliari
Chir Ital. 2009 Sep-Dec;61(5-6):545-9.
Recurrence after conservative thyroid surgery ranges from 7 to 40%. Risk factors for recurrence are female sex, multiple nodules in the resected lobe and lack of postoperative LT4 therapy. Indications for reoperation are suspected malignancy, recurrent thyrotoxicosis and recurrent uninodular or multinodulare goitre. From 2002 to 2008, 2149 total thyroidectomies were performed. Ninety-two patients had a completion thyroidectomy. The indication was recurrent multinodular goitre in 81, recurrent thyrotoxicosis in 3, and suspected malignancy in 8. Bilateral completion thyroidectomy was performed in 63 cases, lobectomy in 27 cases, removal of a mediastinal recurrence in 1 case and removal of a pyramidal remnant in 1 case. Histological examination revealed papillary cancer in 18 patients and follicular cancer in 1. Mean operative time was 140 minutes (range: 60-260). All patients were submitted to a minimum follow-up of 6 months. Temporary hypoparathyroidism occurred in 36 patients (39.1%) and definitive hypoparathyroidism in 7 patients (7.6%). Transient recurrent laryngeal nerve palsy occurred in 3 cases (3.2%) and permanent nerve palsy in 1 (1.1%). In 3 cases (3.2%) surgical revision of haemostasis was necessary for postoperative haemorrhage. Total thyroidectomy is the treatment of choice in multinodular goitre. In the cases in which reoperation is necessary, the intervention must be performed by an experienced surgeon.
甲状腺保守性手术后的复发率在7%至40%之间。复发的危险因素包括女性、切除叶内存在多个结节以及术后未进行左甲状腺素(LT4)治疗。再次手术的指征为疑似恶性肿瘤、复发性甲状腺毒症以及复发性单结节或多结节性甲状腺肿。2002年至2008年期间,共进行了2149例全甲状腺切除术。92例患者接受了甲状腺全切术。其中81例的指征为复发性多结节性甲状腺肿,3例为复发性甲状腺毒症,8例为疑似恶性肿瘤。63例行双侧甲状腺全切术,27例行叶切除术,1例行纵隔复发灶切除术,1例行锥体叶残留切除术。组织学检查发现18例为乳头状癌,1例为滤泡状癌。平均手术时间为140分钟(范围:60 - 260分钟)。所有患者至少接受了6个月的随访。36例患者(39.1%)发生了暂时性甲状旁腺功能减退,7例患者(7.6%)发生了永久性甲状旁腺功能减退。3例患者(3.2%)出现了暂时性喉返神经麻痹,1例患者(1.1%)出现了永久性神经麻痹。3例患者(3.2%)因术后出血需要进行止血手术修正。全甲状腺切除术是多结节性甲状腺肿的首选治疗方法。在需要再次手术的病例中,干预必须由经验丰富的外科医生进行。