[Protective effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure].
作者信息
Liu Ting, He Yong-Wen
机构信息
Department of Infectious Disease, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
出版信息
Zhonghua Gan Zang Bing Za Zhi. 2010 Mar;18(3):222-6. doi: 10.3760/cma.j.issn.1007-3418.2010.03.017.
OBJECTIVE
To evaluate the effect of recombinant HMGB1 A box protein in mouse with acute hepatic failure.
METHOD
Acute hepatic failure was induced by D-galactosamine and lipopolysaccharide in mice. After injection with saline (control) or recombinant HMGB1 A box proteins, the expression of HMGB1 in liver tissues was detected by immunohistochemistry and RT-PCR, and the serum TNFalpha and IL-1beta were quantified.
RESULTS
rHMGB1-Abox protein alleviated the acute liver damage. rHMGB1-Abox protein treatment decreased the expression of HMGB1 in liver tissues and reduced the serum levels of TNFalpha and IL-1beta.
CONCLUSION
rHMGB1-Abox protein can alleviate the acute liver damage and inhibit the expression of HMGB1.
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