点击反应合成具有抗菌和抗病毒活性的ristocetin 苷元衍生的碳水化合物衍生物。
Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.
机构信息
Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary.
出版信息
Bioorg Med Chem Lett. 2010 May 1;20(9):2713-7. doi: 10.1016/j.bmcl.2010.03.080. Epub 2010 Mar 27.
PMID:20381348
Abstract
New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.
摘要
新型里托菌素糖衍生物通过铜催化的 1,3-偶极环加成反应，使用叠氮基里托菌素糖苷元和各种炔丙基糖苷制备。其中一些对革兰氏阳性菌具有活性，并显示出对甲型 H1N1 流感病毒的良好抗病毒活性。
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