一些含有烷基和芳基硫代取代马来酰亚胺的替考拉宁假苷元衍生物的合成与抗菌评价
Synthesis and antibacterial evaluation of some teicoplanin pseudoaglycon derivatives containing alkyl- and arylthiosubstituted maleimides.
作者信息
Csávás Magdolna, Miskovics Adrienn, Szűcs Zsolt, Rőth Erzsébet, Nagy Zsolt L, Bereczki Ilona, Herczeg Mihály, Batta Gyula, Nemes-Nikodém Éva, Ostorházi Eszter, Rozgonyi Ferenc, Borbás Anikó, Herczegh Pál
机构信息
Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary.
Department of Organic Chemistry, University of Debrecen, Debrecen, Hungary.
出版信息
J Antibiot (Tokyo). 2015 Sep;68(9):579-85. doi: 10.1038/ja.2015.33. Epub 2015 Apr 1.
Bis-alkylthio maleimido derivatives have been prepared from teicoplanin pseudoaglycon by reaction of its primary amino group with N-ethoxycarbonyl bis-alkylthiomaleimides. Some of the new derivatives displayed excellent antibacterial activity against resistant bacteria.
通过替考拉宁假苷元的伯氨基与N-乙氧羰基双烷硫基马来酰亚胺反应，制备了双烷硫基马来酰亚胺衍生物。一些新衍生物对耐药菌显示出优异的抗菌活性。
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