Centre for New Antivirals and Antineoplastics, Charles University in Prague, Faculty of Pharmacy, Heyrovského 1203, 50005 Hradec Králové, Czech Republic.
Bioorg Med Chem Lett. 2010 May 1;20(9):2726-8. doi: 10.1016/j.bmcl.2010.03.077. Epub 2010 Mar 25.
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
Transkarbam 12 是十二烷基 6-氨基己酸酯与二氧化碳反应生成的一种氨基甲酸铵，是一种高效、广谱、无毒、无刺激性的经皮渗透增强剂。它可能通过双重机制起作用：其部分活性与角质层中的氨基甲酸盐及其分解有关。释放的铵酯也是一种有效的增强剂，其活性高度依赖于酯基的位置。
Zotero 插件