Transkarbams with terminal branching as transdermal permeation enhancers.

作者信息

Klimentová Jana, Kosák Petr, Vávrová Katerina, Holas Tomás, Novotný Jakub, Hrabálek Alexandr

机构信息

Department of Inorganic and Organic Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, Hradec Králové 50005, Czech Republic.

出版信息

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1712-5. doi: 10.1016/j.bmcl.2008.01.040. Epub 2008 Jan 18.

DOI:10.1016/j.bmcl.2008.01.040

PMID:18242986

Abstract

Transkarbams (T) represent novel group of highly active, non-toxic transdermal permeation enhancers. This study was focused on the influence of small symmetrical terminal branching on their enhancing activity. Series of T with terminal methyl or ethyl branching was prepared and their permeation-enhancing activity was compared to that of their linear analogues. The results showed completely a different behaviour from similarly branched alcohols, supporting the key role of the ammonium-carbamate polar head in the enhancing activity of T.

摘要

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