Badraoui Riadh, Abdelmoula Nouha B, Rebai Tarek
Laboratoire d'Histologie-Embryologic, Faculté de Médecine de Sfax, Tunisie.
Exp Toxicol Pathol. 2011 Jul;63(5):479-82. doi: 10.1016/j.etp.2010.03.008. Epub 2010 Apr 9.
The effects of subchronic exposure to tetrachlorodiphenyl sulfone (TCDS) on hematological parameters [white blood cells (WBC), red blood cells (RBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), hemoglobin (Hb) and hematocrite (Ht) levels] were examined. Oxidative stress in erythrocytes was also assessed by measuring thiobarbituric acid reactive substances (TBARS) and enzyme antioxidant activities [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)]. TCDS was administered orally, dissolved in water, ad libitum to 12 female rats at 28.9 mg/kg/day for 6 or 12 weeks. Results showed that TCDS induced significant decreases in RBC, Hb, and Ht. Whereas MCV, MCH, and MCHC remain unchanged and WBC increased only in the second period of the study. Moreover erythrocyte TBARS level increased, and antioxidant enzyme (SOD, GPx, and CAT) activities decreased. We concluded that TCDS intoxication promotes erythrocyte oxidative damage and disrupt hematological constituents in rats.
研究了亚慢性暴露于四氯二苯砜（TCDS）对血液学参数[白细胞（WBC）、红细胞（RBC）、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）、平均红细胞血红蛋白浓度（MCHC）、血红蛋白（Hb）和血细胞比容（Ht）水平]的影响。还通过测量硫代巴比妥酸反应性物质（TBARS）和酶抗氧化活性[超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）]评估红细胞中的氧化应激。将TCDS溶解于水中，以28.9 mg/kg/天的剂量随意口服给予12只雌性大鼠，持续6周或12周。结果显示，TCDS导致RBC、Hb和Ht显著降低。而MCV、MCH和MCHC保持不变，且仅在研究的第二个阶段WBC增加。此外，红细胞TBARS水平升高，抗氧化酶（SOD、GPx和CAT）活性降低。我们得出结论，TCDS中毒会促进大鼠红细胞的氧化损伤并扰乱血液学成分。
