Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.
Nephrol Dial Transplant. 2010 Nov;25(11):3647-54. doi: 10.1093/ndt/gfq184. Epub 2010 Apr 9.
Guidelines have set goals for risk factor management in chronic kidney disease (CKD) patients. These goals are often not met. In this analysis, we set out to assess the quality of risk factor management in CKD and to identify factors that determine the quality of care (QoC). For that purpose, baseline data of the MASTERPLAN (Multifactorial Approach and Superior Treatment Efficacy in Renal Patients with the Aid of Nurse practitioners) study have been used. MASTERPLAN is a multicentre study which evaluates the effect of a multifactorial intervention in prevalent CKD patients on cardiovascular (CV) events and progression of kidney failure.
QoC was quantified using a score based on the number of 11 defined treatment goals on target. The maximum score per patient was 11.
The average (±SD) QoC score was 6.7 (±1.5). The average score per centre ranged from 5.9 to 6.9. In a multivariable analysis, centre proved to be a significant, independent determinant of QoC with a difference up to 0.7 between centres. This difference remained when adjustments were made for those risk factors primarily treated by pharmacotherapy. Other factors that were significantly related to the QoC were estimated glomerular filtration rate, Caucasian race, diabetes mellitus, diabetic nephropathy as cause of kidney disease and previous kidney transplantation.
In CKD patients, risk factors for progression of kidney failure and CV events were inadequately controlled. Treatment centre proved to be an important determinant of QoC. This data may point towards the physician's interest and preference as important determinants of QoC. This is a potentially modifiable determinant of the quality of patient care [Trial registration ISRCTN registry: 73187232 (http://isrctn.org)].
指南为慢性肾脏病(CKD)患者的危险因素管理设定了目标。但这些目标往往无法实现。在本分析中,我们旨在评估 CKD 患者危险因素管理的质量,并确定决定护理质量(QoC)的因素。为此,使用了 MASTERPLAN(多因素方法和在护士从业者的帮助下提高肾病患者治疗效果)研究的基线数据。MASTERPLAN 是一项多中心研究,评估了多因素干预对常见 CKD 患者心血管(CV)事件和肾功能衰竭进展的影响。
使用基于 11 项既定治疗目标的分数来量化 QoC。每位患者的最高分数为 11 分。
平均(±SD)QoC 评分为 6.7(±1.5)。各中心的平均评分范围为 5.9 至 6.9。在多变量分析中,中心被证明是 QoC 的一个重要的独立决定因素,中心之间的差异高达 0.7。当对主要通过药物治疗的危险因素进行调整时,这种差异仍然存在。与 QoC 显著相关的其他因素包括估计肾小球滤过率、白种人、糖尿病、糖尿病肾病作为肾脏疾病的病因和既往肾移植。
在 CKD 患者中,导致肾衰竭和 CV 事件进展的危险因素控制不足。治疗中心被证明是 QoC 的一个重要决定因素。这些数据可能表明医生的兴趣和偏好是 QoC 的重要决定因素。这是患者护理质量的一个潜在可改变的决定因素[试验注册 ISRCTN 注册表:73187232(http://isrctn.org)]。