Blaschke-Hellmessen R, Schwarze R
Institut für Medizinische Mikrobiologie, Medizinischen Akademie Carl Gustav Carus, Dresden.
Monatsschr Kinderheilkd. 1991 Feb;139(2):92-5.
Altogether 80 newborns at risk were prophylactically treated with 3 x 150,000 IU nystatin/d per os for 14-21 d respectively on every second day for 14-21 d. The content of yeasts in the faeces was determined. In preterm infants with birth-weight below 1500 g the intestinal yeasts--especially Candida albicans--persisted much longer during nystatin application than in infants with higher birthweight and longer gestation-time. In newborns at risk, daily nystatin doses of 3 x 150,000 IU/d are recommended for the duration of disposition for systemic candidosis.
总共80名高危新生儿接受了预防性治疗，每两天口服3×150,000国际单位制霉菌素/天，持续14 - 21天。测定了粪便中的酵母菌含量。出生体重低于1500克的早产儿在应用制霉菌素期间，肠道酵母菌——尤其是白色念珠菌——持续存在的时间比出生体重较高、妊娠期较长的婴儿长得多。对于高危新生儿，建议在系统性念珠菌病的处置期间，每天给予3×150,000国际单位的制霉菌素剂量。
