Fung K, Clayton C
Rockefeller University, New York, NY.
Mol Biochem Parasitol. 1991 Apr;45(2):261-4. doi: 10.1016/0166-6851(91)90093-l.
Trypanosomes compartmentalise the first 9 enzymes of glycolysis and glycerol metabolism in peroxisome-like microbodies known as glycosomes. The identity of the sequences that direct proteins into the glycosome has until now been uncertain. We show here that the peroxisomal tripeptide entry signal is sufficient to cause association of a bacterial enzyme with the glycosomes of Trypanosoma brucei. However, it works less efficiently than the C-terminal 21 amino acids of trypanosome glycosomal phosphoglycerate kinase.
锥虫将糖酵解和甘油代谢的前9种酶分隔在称为糖体的过氧化物酶体样微体中。迄今为止，引导蛋白质进入糖体的序列的身份尚不确定。我们在此表明，过氧化物酶体三肽进入信号足以使一种细菌酶与布氏锥虫的糖体发生关联。然而，它的效率不如锥虫糖体磷酸甘油酸激酶的C末端21个氨基酸。
