评估他莫昔芬在预防手术切口后肥厚性瘢痕中的作用。
Evaluating tamoxifen effect in the prevention of hypertrophic scars following surgical incisions.
机构信息
Department of Surgery, Shahid Beheshti University of Medical Sciences, Shohada Tahrish Hospital, Tehran, Iran.
出版信息
Dermatol Surg. 2010 May;36(5):665-9. doi: 10.1111/j.1524-4725.2010.01526.x. Epub 2010 Apr 1.
OBJECTIVES
To evaluate the clinical utility of tamoxifen in the prevention of hypertrophic scars (HTSs).
MATERIAL AND METHODS
In a double-blind randomized clinical trial, 300 patients with a history of HTSs who underwent surgery with different skin incisions were assigned randomly to two groups. The first received tamoxifen tablets postoperatively according to a standard protocol, and the control group received placebo. After 2 months, the two groups were compared according to the development of HTSs, and the results were analyzed.
RESULTS
The studied population comprised 235 men (78.7%) and 65 women (21.7%) who developed HTSs after surgical incision, 138 of whom (92%) were in the study group and 78 (52%) in the control group.
CONCLUSION
Tamoxifen seems to be an effective agent in the prevention of HTSs after surgery.
目的
评估他莫昔芬在预防肥厚性瘢痕（HTSs）中的临床应用价值。
材料与方法
在一项双盲随机临床试验中，将 300 例有 HTSs 病史、接受不同皮肤切口手术的患者随机分为两组。第一组根据标准方案术后接受他莫昔芬片治疗，对照组给予安慰剂。2 个月后，根据 HTSs 的发展情况对两组进行比较，并分析结果。
结果
研究人群包括 235 名男性（78.7%）和 65 名女性（21.7%），他们在手术后切口处形成了 HTSs，其中 138 名（92%）在研究组，78 名（52%）在对照组。
结论
他莫昔芬似乎是预防手术后 HTSs 的有效药物。
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