Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Andrologia. 2010 Apr;42(2):117-20. doi: 10.1111/j.1439-0272.2009.00966.x.
The purpose of this study was to verify the effect of testosterone depletion on healing of surgical skin wounds at different ages and post-operative periods. Forty-four Wistar male rats were divided into four groups: Group 1Y (n = 11) - young control, sham-operated rats (30-day old); Group 1A (n = 10) - adult control, sham-operated rats (3 to 4-month old); Group 2Y (n = 10) - young rats after bilateral orchiectomy; and Group 2A (n = 11) - adult rats after bilateral orchiectomy. After 6 months, a linear incision was performed on the dorsal region of the animals. The resistance of the wound healing was measured in a skin fragment using a tensiometer, on the 7th and 21st post-operative days. The wound healing resistance was higher in Group 1Y than in Group 2Y after 7 days (P < 0.05). Wound healing resistance at 21 days was higher than at 7 days in all groups (P < 0.05). Late wound healing resistance was not different between young and adult rats. It is concluded that bilateral orchiectomy diminished the wound healing resistance only in young animals at the 7th post-operative day.
本研究旨在验证睾丸激素耗竭对不同年龄和术后时期手术皮肤伤口愈合的影响。将 44 只 Wistar 雄性大鼠分为四组：1Y 组（n = 11）-年轻对照组，假手术大鼠（30 日龄）；1A 组（n = 10）-成年对照组，假手术大鼠（3 至 4 月龄）；2Y 组（n = 10）-双侧去势的年轻大鼠；2A 组（n = 11）-双侧去势的成年大鼠。6 个月后，在动物背部区域进行线性切口。在第 7 天和第 21 天，使用张力计测量皮肤片段的伤口愈合阻力。第 7 天，1Y 组的伤口愈合阻力高于 2Y 组（P < 0.05）。所有组的第 21 天的伤口愈合阻力均高于第 7 天（P < 0.05）。年轻和成年大鼠的晚期伤口愈合阻力没有差异。结论：双侧去势仅在术后第 7 天降低了年轻动物的伤口愈合阻力。
