Department of Pharmacy, University of Parma, Parma, Italy.
Skin Res Technol. 2010 Feb;16(1):125-30. doi: 10.1111/j.1600-0846.2009.00407.x.
BACKGROUND/PURPOSE: The aim of this work was to study the in vivo performance of an innovative drug-delivery system, denominated Patch-non-Patch, using the tape-stripping technique.
The stratum corneum distribution of lidocaine, chosen as the model drug, was studied on human volunteers, using the tape-stripping technique. The amount of lidocaine recovered in tape strips was quantified using high-pressure liquid chromatography.
When lidocaine was included in the film, the model drug was found in the stratum corneum already after 5 min of contact time. The increase in the application time increased lidocaine recovery in the stratum corneum, although only the extreme application times (5-10 min and 24 h) were significantly different. The profile of lidocaine recovered in the stratum corneum from the film was comparable with that obtained from the equivalent water solution, confirming the conclusion of in vitro permeation data that the film does not reduce lidocaine mobility inside the film and its partitioning into the stratum corneum.
The bioadhesive film studied in this work seems to be an effective system for the delivery of drugs to the skin.
背景/目的：本研究旨在采用胶带撕脱技术，研究一种名为 Patch-non-Patch 的新型药物传递系统的体内性能。
采用胶带撕脱技术，对人体志愿者进行研究，以利多卡因（选择作为模型药物）在角质层中的分布为研究对象。采用高效液相色谱法对胶带中回收的利多卡因含量进行定量。
当利多卡因包含在薄膜中时，在接触 5 分钟后，模型药物就已经存在于角质层中。增加应用时间会增加角质层中利多卡因的回收率，但只有极端应用时间（5-10 分钟和 24 小时）差异显著。从薄膜中回收的利多卡因在角质层中的分布与从等效水溶液中获得的分布相似，这证实了体外渗透数据的结论，即薄膜不会降低薄膜内利多卡因的迁移率及其在角质层中的分配。
本研究中所研究的生物粘附薄膜似乎是一种向皮肤递送药物的有效系统。
Zotero 插件