1st Department of Obstetrics and Gynecology of the University of Athens, Alexandra Hospital, Athens, Greece.
Fertil Steril. 2010 Nov;94(6):2470-2. doi: 10.1016/j.fertnstert.2010.03.007. Epub 2010 Apr 10.
In this study the immunohistochemical expression of matrix metalloproteinases 1, 2, 3, and 9, tissue inhibitors (TIMPs) 1 and 2, and cathepsin-D in ovarian endometriomas were correlated with the clinical severity of endometriosis (i.e., presence of chronic pelvic pain [CPP] and American Society of Reproductive Medicine [ASRM] scores). Positive expression of proteases and their inhibitors was found more frequently in cases with low ASRM scores, whereas presence of CPP correlated significantly with absence of expression of TIMPs 1 and 2, indicating, first, that production of these enzymes is more active during the initial phases of the evolution of ovarian endometriosis, declining as fibrosis develops, and second, that expression of TIMPs seems to play a role in the development of CPP.
本研究分析了基质金属蛋白酶 1、2、3 和 9，组织抑制剂（TIMPs）1 和 2，以及组织蛋白酶-D 在卵巢子宫内膜异位症中的免疫组化表达，并与子宫内膜异位症的临床严重程度（即慢性盆腔痛 [CPP] 和美国生殖医学学会 [ASRM] 评分）相关。蛋白酶及其抑制剂的阳性表达在 ASRM 评分较低的病例中更为常见，而 CPP 的存在则与 TIMP1 和 TIMP2 表达的缺失显著相关，这表明，首先，这些酶的产生在卵巢子宫内膜异位症的早期阶段更为活跃，随着纤维化的发展而减少，其次，TIMP 的表达似乎在 CPP 的发展中发挥作用。
