Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Pediatrics. 2010 May;125(5):e1241-5. doi: 10.1542/peds.2009-1815. Epub 2010 Apr 12.
Corticosteroid treatment is an important therapeutic modality for many pediatric medical conditions including acute lymphoblastic leukemia. However, steroid-induced behavioral and mood abnormalities are common and potentially disabling adverse effects that have been widely reported in the pediatric literature. From this case series, we report the efficacy of risperidone in 3 children with acute lymphoblastic leukemia who developed steroid-related mood and psychotic symptoms during treatment with prednisone and dexamethasone. Risperidone is an effective short-term pharmacologic agent for controlling steroid-related psychiatric adverse effects when cessation or dose reduction of steroid therapy is not an option.
皮质类固醇治疗是许多儿科疾病的重要治疗方式，包括急性淋巴细胞白血病。然而，皮质类固醇引起的行为和情绪异常是常见的，也是潜在的致残的不良反应，在儿科文献中已有广泛报道。从这个病例系列中，我们报告了利培酮在 3 名接受泼尼松龙和地塞米松治疗的急性淋巴细胞白血病患儿中的疗效，这些患儿在治疗过程中出现了与类固醇相关的情绪和精神病症状。当不能停止或减少类固醇治疗时，利培酮是一种有效的短期药物，可控制与类固醇相关的精神不良反应。
