Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata 700026, India.
Hum Exp Toxicol. 2011 Feb;30(2):165-70. doi: 10.1177/0960327110368694. Epub 2010 Apr 12.
Arsenic is a naturally occurring metalloid that has been associated with increased incidence of human cancers in certain highly exposed populations. This present work aimed to study whether arsenic plays any role in the increased incidence of blood cancer among residents of West Bengal, India, which is one of the worst arsenic-affected areas of the world. Our study group included both blood cancer patients and age-, sex-matched healthy controls. We studied the arsenic concentration in the hair and nail samples of our study group. We found significantly higher arsenic concentration in the biological tissues of patients, which also correlated with their greater incidence of chromosomal aberrations. Thus, arsenic may act as a predisposing factor for blood cancer.
砷是一种天然存在的类金属元素，已被证实与某些高暴露人群中人类癌症发病率的增加有关。本研究旨在探讨砷是否在印度西孟加拉邦居民中血液癌发病率的增加中起作用，该邦是世界上受砷污染最严重的地区之一。我们的研究组包括血液癌患者和年龄、性别匹配的健康对照组。我们研究了研究组中头发和指甲样本中的砷浓度。我们发现患者的生物组织中的砷浓度明显更高，这也与他们更高的染色体异常发生率相关。因此，砷可能是血液癌的一个诱发因素。
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